Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.

@article{Krek1994NegativeRO,
  title={Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.},
  author={Wilhelm Krek and Mark E. Ewen and Suhag Shirodkar and Zoltan Arany and William G Kaelin and David M. Livingston},
  journal={Cell},
  year={1994},
  volume={78 1},
  pages={161-72}
}
Cyclin A-kinase, an enzyme required for coordinating S phase progression, forms stable in vivo complexes with E2F-1, a growth-promoting transcription factor, which binds to the retinoblastoma gene product and is involved in the timely activation of genes whose products contribute to G1 exit and S phase traversal. Complex formation results in a negative biochemical effect of cyclin A-kinase: the shut-off of E2F-1-dependent DNA binding function in S/G2. Thus, specific and timely cell cycle… CONTINUE READING
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