Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.

  title={Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.},
  author={David Chetrit and Lior Barzilay and Galit Horn and Tom Bielik and Nechama I. Smorodinsky and Marcelo Ehrlich},
  journal={The Journal of biological chemistry},
  volume={286 7},
Mitotic cells undergo extensive changes in shape and size through the altered regulation and function of their membrane trafficking machinery. Disabled 2 (Dab2), a multidomain cargo-specific endocytic adaptor and a mediator of signal transduction, is a potential integrator of trafficking and signaling. Dab2 binds effectors of signaling and trafficking that localize to different intracellular compartments. Thus, differential localization is a putative regulatory mechanism of Dab2 function… CONTINUE READING


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