Negative regulation of the SH2-homology-containing protein-tyrosine phosphatase-1 (Shp-1) P2 promoter by the HTLV-1 tax oncoprotein

@article{Cheng2006NegativeRO,
  title={Negative regulation of the SH2-homology-containing protein-tyrosine phosphatase-1 (Shp-1) P2 promoter by the HTLV-1 tax oncoprotein},
  author={Jihua Cheng and Andre R Kydd and Koichi Nakase and Kristin M Noonan and Akikazu Murakami and Hong Tao and Q. K. Zhu and Wayne A. Marasco},
  journal={Retrovirology},
  year={2006},
  volume={3},
  pages={P12 - P12}
}
Expression of SH(2)-homology-containing protein-tyrosine phosphatase-1 (SHP-1), a candidate tumor suppressor, is repressed in human T-cell leukemia virus type-1 (HTLV-1)-transformed lymphocyte cell lines, adult T-cell leukemia (ATL) cells, and in other hematologic malignancies. However, the mechanisms underlying regulation and repression of SHP-1 remain unclear. Herein, we cloned the putative full-length, hematopoietic cell-specific SHP-1 P2 promoter and identified the "core" promoter regions… CONTINUE READING

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The HTLV-1 Tax interactome

Retrovirology • 2008
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PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

The Journal of biological chemistry • 2007
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