Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition.

@article{Kraus1996NegativeRO,
  title={Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition.},
  author={Eva Kraus and Doris Lambracht and Kurt Wonigeit and Thomas H{\"u}nig},
  journal={European journal of immunology},
  year={1996},
  volume={26 11},
  pages={2582-6}
}
The cytolytic activity of human and mouse natural killer (NK) cells is negatively regulated by self major histocompatibility complex (MHC) class I molecules on potential target cells. In the rat, protection by RT1 class I gene products has so far not been formally shown although the complex effects of foreign and self RT1 genes on polyclonal NK cell activity suggest that MHC recognition can have both stimulatory and inhibitory effects. Here we report that the expression of self-MHC class I… CONTINUE READING