Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.

@article{Knauf2001NegativeRO,
  title={Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.},
  author={U Knauf and Claude Tschopp and Hermann Gram},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 16},
  pages={5500-11}
}
Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 in response to mitogens and cellular stress. Here we demonstrate that phosphorylation of eIF4E via MNK1 is mediated via the activation of either… CONTINUE READING
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