Negative regulation of inflammation by Fas ligand expression on the vascular endothelium.

@article{Walsh1999NegativeRO,
  title={Negative regulation of inflammation by Fas ligand expression on the vascular endothelium.},
  author={Kenneth Walsh and Masataka Sata},
  journal={Trends in cardiovascular medicine},
  year={1999},
  volume={9 1-2},
  pages={34-41}
}
It is generally believed that the vascular endothelium serves as a barrier to inflammation by providing a nonadherent surface to leukocytes. Recently, we reported that vascular endothelial cells (ECs) express Fas ligand, which functions to actively inhibit inflammation by inducing apoptosis in Fas-bearing leukocytes. The inflammatory cytokine TNF alpha downregulates Fas ligand expression with an accompanying decrease in EC cytotoxicity toward Fas-bearing cells in co-culture. Endothelial Fas… CONTINUE READING

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