Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.

@article{Lee2004NegativeRO,
  title={Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.},
  author={Heehyoung Lee and Natalie Rezai-Zadeh and Edward Seto},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 2},
  pages={
          765-73
        }
}
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues of histone and nonhistone proteins. Recent studies suggest that they are key regulators of many cellular events, including cell proliferation and cancer development. Human class I HDACs possess homology to the yeast RPD3 protein and include HDAC1, HDAC2, HDAC3, and HDAC8. While HDAC1, HDAC2, and HDAC3 have been characterized extensively, almost nothing is known about HDAC8. Here we report… CONTINUE READING
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