Negative regulation of dermal fibroblasts by enlarged adipocytes through release of free fatty acids.

@article{Ezure2011NegativeRO,
  title={Negative regulation of dermal fibroblasts by enlarged adipocytes through release of free fatty acids.},
  author={Tomonobu Ezure and Satoshi Amano},
  journal={The Journal of investigative dermatology},
  year={2011},
  volume={131 10},
  pages={2004-9}
}
Subcutaneous adipose tissue lies just beneath the dermal layer, but the interaction between the two types of tissue remains obscure. Recently, we reported that obesity is associated with decreased dermal elasticity. To investigate the mechanism of the adipose tissue/dermal interaction, fibroblasts were cocultured with small or enlarged adipocytes, using a membrane insert to prevent direct contact. Enlarged adipocytes reduced 3T3-L1 fibroblast proliferation and gene expression of collagen (I)-α1… CONTINUE READING
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