Negative regulation of daptomycin production by DepR2, an ArsR-family transcriptional factor


Daptomycin, a lipopeptide antibiotic potently active against Gram-positive bacterial pathogens, is produced by Streptomyces roseosporus, but the transcriptional regulation on its biosynthesis is not fully understood. Here, we report that DepR2, an ArsR-family transcriptional regulator isolated previously by DNA-affinity purification, interacts directly with… (More)
DOI: 10.1007/s10295-017-1983-3


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