Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.

@article{Omori2010NegativeRO,
  title={Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.},
  author={Yoshihiro Omori and Taro Chaya and Kimiko Katoh and Naoko Kajimura and Shigeru Sato and Koichiro Muraoka and Shinji Ueno and Toshiyuki Koyasu and Mineo Kondo and Takahisa Furukawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 52},
  pages={22671-6}
}
Cilia function as cell sensors in many organs, and their disorders are referred to as "ciliopathies." Although ciliary components and transport machinery have been well studied, regulatory mechanisms of ciliary formation and maintenance are poorly understood. Here we show that male germ cell-associated kinase (Mak) regulates retinal photoreceptor ciliary length and subcompartmentalization. Mak was localized both in the connecting cilia and outer-segment axonemes of photoreceptor cells. In the… CONTINUE READING
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