Negative regulation of caspase-3 expression in the neonatal cerebral cortex by α2A-adrenoceptors

Abstract

Antisense oligonucleotide to α2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of α2-adrenoceptors was confirmed by the possibility… (More)
DOI: 10.1007/s10517-007-0088-9

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