Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

  title={Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1},
  author={Hongkang Xi and Kenneth J. Katschke and Karim Y. Helmy and Paige A J Wark and Noelyn M Kljavin and Hilary F. Clark and Jeffrey R Eastham-Anderson and Theresa Shek and Merone Roose-Girma and Nico Ghilardi and Menno van Lookeren Campagne},
  booktitle={The Journal of experimental medicine},
Multiple sclerosis and its preclinical model, experimental autoimmune encephalomyelitis, are marked by perivascular inflammation and demyelination. Myeloid cells, derived from circulating progenitors, are a prominent component of the inflammatory infiltrate and are believed to directly contribute to demyelination and axonal damage. How the cytotoxic activity of these myeloid cells is regulated is poorly understood. We identify CMRF-35-like molecule-1 (CLM-1) as a negative regulator of… CONTINUE READING
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