Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells.

@article{Lahn1999NegativeRO,
  title={Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells.},
  author={Michael Lahn and Arihiko Kanehiro and Katsuyuki Takeda and Anthony Joetham and J{\"u}rgen Schwarze and Gabriele J Koehler and Rebecca L O'brien and Erwin W. Gelfand and Willi K. Born},
  journal={Nature medicine},
  year={1999},
  volume={5 10},
  pages={1150-6}
}
The mechanisms regulating airway function are complex and still poorly understood. In diseases such as asthma, involvement of immune-dependent mechanisms has been suggested in causing changes in airway responsiveness to bronchoconstrictors. We now demonstrate that gammadelta T cells can regulate airway function in an alphabeta T cell-independent manner, identifying them as important cells in pulmonary homeostasis. This function of gammadelta T cells differs from previously described immune… CONTINUE READING

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