Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis.

@article{Leach1998NegativeRO,
  title={Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis.},
  author={Steven D. Leach and Caroline D. Scatena and C J Keefer and Holly A. Goodman and Si Young Song and Linglin Yang and Jennifer A. Pietenpol},
  journal={Cancer research},
  year={1998},
  volume={58 15},
  pages={3231-6}
}
The G2 cell cycle checkpoint protects cells from potentially lethal mitotic entry after DNA damage. This checkpoint involves inhibitory phosphorylation of Cdc2 at the tyrosine-15 (Y15) position, mediated in part by the Wee1 protein kinase. Recent evidence suggests that p53 may accelerate mitotic entry after DNA damage and that the override of the G2 checkpoint may play a role in the induction of apoptosis by p53. To determine the biochemical mechanism by which p53 inactivates the G2 checkpoint… CONTINUE READING

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