Negative regulation of TLR-signaling pathways by activating transcription factor-3.

@article{Whitmore2007NegativeRO,
  title={Negative regulation of TLR-signaling pathways by activating transcription factor-3.},
  author={Mark M. Whitmore and Amaya Iparraguirre and Lindsey Kubelka and Wolfgang Weninger and Tsonwin Hai and Bryan Raymond George Williams},
  journal={Journal of immunology},
  year={2007},
  volume={179 6},
  pages={3622-30}
}
Activating transcription factor-3 (ATF3) is rapidly induced by LPS in mouse macrophages and regulates TLR4 responses. We show that ATF3 is rapidly induced by various TLRs in mouse macrophages and plasmacytoid dendritic cells (DCs), as well as plasmacytoid and myeloid subsets of human DCs. In primary macrophages from mice with a targeted deletion of the atf3 gene (ATF3-knockout (KO)), TLR-stimulated levels of IL-12 and IL-6 were elevated relative to responses in wild-type macrophages. Similarly… CONTINUE READING

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