Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.

@article{Hamerman2016NegativeRO,
  title={Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.},
  author={Jessica A. Hamerman and Jessica Pottle and Minjian Ni and Yantao He and Zhong-Yin Zhang and Jane H Buckner},
  journal={Immunological reviews},
  year={2016},
  volume={269 1},
  pages={212-27}
}
Toll-like receptors (TLR) are transmembrane pattern recognition receptors that recognize microbial ligands and signal for production of inflammatory cytokines and type I interferon in macrophages and dendritic cells (DC). Whereas TLR-induced inflammatory mediators are required for pathogen clearance, many are toxic to the host and can cause pathological inflammation when over-produced. This is demonstrated by the role of TLR-induced cytokines in autoimmune diseases, such as rheumatoid arthritis… CONTINUE READING