Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.

@article{Harzenetter2007NegativeRO,
  title={Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.},
  author={Marit D. Harzenetter and Alexander R. Novotny and Petra Gais and Carlos Alberto Molina and Felicitas Altmayr and Bernhard Holzmann},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={607-15}
}
Communication between the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation. CGRP may inhibit the activities of both innate and adaptive immune cells, but the molecular pathways underlying this function are largely unknown. In this study, we identify CGRP as a potent inhibitor of TLR-stimulated production of inflammatory mediators, such as TNF-alpha and CCL4, by murine dendritic cells… CONTINUE READING

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