Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.

@article{Mattila2005NegativeRO,
  title={Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.},
  author={Elina M. Mattila and Teijo Pellinen and Jonna Nevo and Karoliina Vuoriluoto and Antti Arjonen and Johanna Ivaska},
  journal={Nature cell biology},
  year={2005},
  volume={7 1},
  pages={78-85}
}
Integrin-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signalling pathways. So far, integrins have been mainly shown to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signalling. Here we show that a collagen-binding integrin alpha(1)beta(1) functions as a negative regulator of epidermal growth factor receptor (EGFR) signalling through the activation of a protein… CONTINUE READING