Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.

@article{Paredes2011NegativeRB,
  title={Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.},
  author={Juan C Paredes and David P. Welchman and Micka{\"e}l Poidevin and Bruno Lemaitre},
  journal={Immunity},
  year={2011},
  volume={35 5},
  pages={770-9}
}
Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidoglycan. We have performed a systematic analysis of catalytic PGRP function using deletions, separately and in combination. Our findings support the role of PGRP-LB as a negative regulator of the Imd pathway and brought to light a synergy of PGRP… CONTINUE READING
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