Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia.

@article{Voso2002NegativePV,
  title={Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia.},
  author={Maria Teresa Voso and Francesco D'alo' and Rossana Putzulu and Luca Mele and Alessandra Scardocci and Patrizia Chiusolo and Roberto Latagliata and Francesco Lo-Coco and Sergio Rutella and Livio Pagano and Stefan Hohaus and Giuseppe Leone},
  journal={Blood},
  year={2002},
  volume={100 8},
  pages={2703-7}
}
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmental mutagens, carcinogens, and anticancer drugs. GST polymorphisms resulting in decreased enzymatic activity have been associated with several types of solid tumors. We determined the prognostic significance of the deletion of 2 GST subfamilies genes, M1 and T1, in patients with acute myeloid leukemia (AML). Using polymerase chain reactions, we analyzed the GSTM1 and GSTT1 genotype in 106 patients… CONTINUE READING