Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review

  title={Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review},
  author={Jung Bin Kim and Jin-Man Jung and Moon-Ho Park and Eun Ju Lee and Do-Young Kwon},
  journal={Journal of the Neurological Sciences},
INTRODUCTION Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. METHODS We collected the patients with negative myoclonus who… Expand
Negative myoclonus associated with tramadol use
It is suggested that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose. Expand
Negative myoclonus associated with pregabalin
It is suggested that pregabalin can cause NM even in patients without a history of seizures, and an 80-year-old man presented with multifocal NM and confusion, which resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of preGabalin. Expand
Myoclonus and Altered Mental Status Induced by Single Dose of Gabapentin in a Patient With End-Stage Renal Disease: A Case Report and Literature Review.
This data indicates that levetiracetam seizure prophylaxis in craniotomy patients at high risk for postoperative seizures in people with epilepsy is a viable option and should be considered in the treatment of epilepsy. Expand
Pregabalin-associated movement disorders: A literature review
In the literature, the majority of the cases did not report information about timeline events, neurological examination details, or electrodiagnostic studies, so the best management for all MDs is probably PGB withdrawal. Expand
Continuous epileptic negative myoclonus as the first seizure type in atypical benign epilepsy with centrotemporal spikes
Whether benzodiazepines are viable as a choice of BECTS variants with electrical status epilepticus in sleep when ENM is the first symptom still needs a large sample evidence-based observation. Expand
Negative myoclonus as the leading symptom in acute cefepime neurotoxicity
An 86-year-old woman diagnosed with hospital-acquired pneumonia with Pseudomonas aeruginosa is suggested to have a link of the negative myoclonus to acute cefepime neurotoxicity, which may occur without or with minimal alteration of mental status, thus extending its spectrum of clinical presentation. Expand
Immediate and controlled-release pregabalin for the treatment of epilepsy
PGB CR failed to prove superior to placebo in a randomized placebo-controlled trial on 323 subjects with drug-resistant FOE, although it was just as tolerable, and is not currently licensed for epilepsy. Expand


Myoclonus induced by the use of gabapentin.
A 69-year-old female who underwent diskectomy and foraminotomy and postoperatively complained of paresthesia in her left leg, which was thought to be due to root manipulation during surgery, was given tramadol, an oral opioid agonist, and GBP. Expand
Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain
Clinical aspects and electrophysiological data such as polygraphic studies, electroencephalography, and measurement of somatosensory evoked potentials support the cortical origin of negative myoclonus. Expand
Pregabalin associated asterixis.
Pregabalin was introduced as a new GABA-ergic drug in clinical practice with similar indications as gabapentin for the treatment of epilepsy and neuropathic pain and comparable side effects of both drugs can be expected. Expand
Myoclonic disorders: a practical approach for diagnosis and treatment
It is essential to take a good history, to clinically characterize myoclonus and to look for additional findings on examination in order to limit the list of possible investigations. Expand
Negative myoclonus. An overview of its clinical features, pathophysiological mechanisms, and management
Simultaneous EEG-EMG monitoring demonstrating the association of NM with an epileptic potential is consistent with the diagnosis of ENM, and the participation of premotor, primary motor, primary sensory, and supplementary motor areas in the genesis of NM is suggested. Expand
Gabapentin–induced severe myoclonus in a patient with impaired renal function
A 66-year-old male patient presented with severe spontaneous brief jerks of all extremities resulting in repeated falls and a markedly increased gabapentin serum concentration amounting to values well above the assumed upper limit of the therapeutical range was confirmed. Expand
Gabapentin‐Induced myoclonus: Case report
A novel diagnostic approach to patients with myoclonus
A novel diagnostic eight-step algorithm to help clinicians accurately, efficiently and cost-effectively diagnose myoclonus is proposed, and for the first time, next-generation sequencing (NGS) is incorporated in a diagnostic algorithm for the disorder. Expand
Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain
Patients treated with pregabalin who experience sudden behavioral changes or mycloni should be investigated for this possible side effect, and preGabalin should be reduced or discontinued if myocloni or status epilepticus occurs. Expand
Asterixis Related to Gabapentin as a Cause of Falls
A case of asterixis is presented as a cause of falls and near falls in a patient with metastatic breast cancer and normal mental status who was receiving gabapentin, and there have been no published reports implicating negative myoclonus as aCause of falls in adults. Expand