Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review

@article{Kim2017NegativeMI,
  title={Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review},
  author={Jung Bin Kim and Jin-Man Jung and Moon-Ho Park and Eun Ju Lee and Do-Young Kwon},
  journal={Journal of the Neurological Sciences},
  year={2017},
  volume={382},
  pages={36-39}
}
INTRODUCTION Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. METHODS We collected the patients with negative myoclonus who… Expand
Negative myoclonus associated with tramadol use
TLDR
It is suggested that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose. Expand
Negative myoclonus associated with pregabalin
TLDR
It is suggested that pregabalin can cause NM even in patients without a history of seizures, and an 80-year-old man presented with multifocal NM and confusion, which resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of preGabalin. Expand
Myoclonus and Altered Mental Status Induced by Single Dose of Gabapentin in a Patient With End-Stage Renal Disease: A Case Report and Literature Review.
TLDR
This data indicates that levetiracetam seizure prophylaxis in craniotomy patients at high risk for postoperative seizures in people with epilepsy is a viable option and should be considered in the treatment of epilepsy. Expand
Pregabalin-associated movement disorders: A literature review
TLDR
In the literature, the majority of the cases did not report information about timeline events, neurological examination details, or electrodiagnostic studies, so the best management for all MDs is probably PGB withdrawal. Expand
Continuous epileptic negative myoclonus as the first seizure type in atypical benign epilepsy with centrotemporal spikes
TLDR
Whether benzodiazepines are viable as a choice of BECTS variants with electrical status epilepticus in sleep when ENM is the first symptom still needs a large sample evidence-based observation. Expand
Negative myoclonus as the leading symptom in acute cefepime neurotoxicity
TLDR
An 86-year-old woman diagnosed with hospital-acquired pneumonia with Pseudomonas aeruginosa is suggested to have a link of the negative myoclonus to acute cefepime neurotoxicity, which may occur without or with minimal alteration of mental status, thus extending its spectrum of clinical presentation. Expand
Immediate and controlled-release pregabalin for the treatment of epilepsy
TLDR
PGB CR failed to prove superior to placebo in a randomized placebo-controlled trial on 323 subjects with drug-resistant FOE, although it was just as tolerable, and is not currently licensed for epilepsy. Expand

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