Negative inotropic effects of propofol as evaluated by the regional preload recruitable stroke work relationship in chronically instrumented dogs.

@article{Pagel1993NegativeIE,
  title={Negative inotropic effects of propofol as evaluated by the regional preload recruitable stroke work relationship in chronically instrumented dogs.},
  author={Paul S. Pagel and David C. Warltier},
  journal={Anesthesiology},
  year={1993},
  volume={78 1},
  pages={
          100-8
        }
}
BACKGROUND Propofol anesthesia often is associated with marked decreases in arterial blood pressure. Previous investigations in vivo have provided conflicting reasons for this clinical finding, including propofol-induced decreases in preload or afterload and/or direct myocardial depressant effects. Interpretation of the results of these studies is complicated by use of indices of myocardial contractility that may only indirectly indicate changes in inotropic state or are significantly dependent… CONTINUE READING
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