Negative inotropic effects of angiotensin II, endothelin-1 and phenylephrine in indo-1 loaded adult mouse ventricular myocytes.

@article{Sakurai2002NegativeIE,
  title={Negative inotropic effects of angiotensin II, endothelin-1 and phenylephrine in indo-1 loaded adult mouse ventricular myocytes.},
  author={Kiyoharu Sakurai and Ikuo Norota and Hisao Tanaka and Isao Kubota and Hitonobu Tomoike and Masao Endo},
  journal={Life sciences},
  year={2002},
  volume={70 10},
  pages={
          1173-84
        }
}
Angiotensin II (Ang II). endothelin-1 (ET-1) and phenylephrine are receptor agonists that share the signal transduction acting through acceleration of phosphoinositide hydrolysis in the heart. Because the regulation of myocardial contractility induced by these receptor agonists shows a wide range of species-dependent variation among experimental animals, we carried out experiments to elucidate the mechanism of contractile regulation induced by these agents in mice which are employed currently… CONTINUE READING
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