Corpus ID: 27008341

Negative inotropic effect of verapamil, nifedipine and prenylamine and its reversal by calcium or isoproterenol.

@article{Mattiazzi1983NegativeIE,
  title={Negative inotropic effect of verapamil, nifedipine and prenylamine and its reversal by calcium or isoproterenol.},
  author={A. Mattiazzi and A. Garay},
  journal={Archives internationales de physiologie et de biochimie},
  year={1983},
  volume={91 3},
  pages={
          133-44
        }
}
  • A. Mattiazzi, A. Garay
  • Published 1983
  • Chemistry, Medicine
  • Archives internationales de physiologie et de biochimie
The type of antagonism between verapamil, nifedipine or prenylamine and calcium or isoproterenol on myocardial contractility, was investigated in cat papillary muscles. Dose response curves to calcium or to isoproterenol were performed in the absence and presence of a single dose of either verapamil, nifedipine or prenylamine. Non significantly different maximum values of tension (T) and maximal rate of rise of tension (+dT/dtmax) were obtained at the "plateau" of the dose responses curves to… Expand
Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart
TLDR
It is suggested that anipamil, in the isolated rabbit heart, possesses a peculiar pharmacological profile, since its calcium channel blocking activity is confined to the myocardial muscle. Expand
Biphasic dose-response relationship observed with Bay k 8644 on atrioventricular nodal conduction inhibited by verapamil
TLDR
In the AV node depressed by a calcium channel blocker, Bay k 8644 gives rise to a bell-shaped dose-response relationship of its verapamilantagonistic action and the reversal of this action by high doses can be observed after both administration of either calcium or Bay k 9644 in moderate doses. Expand
Effects of Eugenol, an Essential Oil, on the Mechanical and Electrical Activities of Cardiac Muscle
TLDR
It is suggested that EUG depresses force without affecting the contractile machinery and its action is the only dependent blockade of the calcium inward current. Expand
Eucalyptol, an essential oil, reduces contractile activity in rat cardiac muscle.
TLDR
It is suggested that eucalyptol depresses force development, probably acting as a calcium channel blocker, in male Wistar rats weighing 250 to 300 g. Expand
Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs
TLDR
This platform has developed a platform that combines machine learning paired with brightfield optical flow as a simple and robust tool that can automate the detection of cardiomyocyte drug effects and serves as a widely applicable screening tool to characterize the effects of drugs on cardiomeocyte function. Expand