• Corpus ID: 27008341

Negative inotropic effect of verapamil, nifedipine and prenylamine and its reversal by calcium or isoproterenol.

  title={Negative inotropic effect of verapamil, nifedipine and prenylamine and its reversal by calcium or isoproterenol.},
  author={Alicia Mattiazzi and A Garay},
  journal={Archives internationales de physiologie et de biochimie},
  volume={91 3},
  • A. Mattiazzi, A. Garay
  • Published 1 September 1983
  • Biology, Chemistry, Medicine
  • Archives internationales de physiologie et de biochimie
The type of antagonism between verapamil, nifedipine or prenylamine and calcium or isoproterenol on myocardial contractility, was investigated in cat papillary muscles. Dose response curves to calcium or to isoproterenol were performed in the absence and presence of a single dose of either verapamil, nifedipine or prenylamine. Non significantly different maximum values of tension (T) and maximal rate of rise of tension (+dT/dtmax) were obtained at the "plateau" of the dose responses curves to… 
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