Negative glucocorticoid receptor response elements and their role in glucocorticoid action.

@article{Dostert2004NegativeGR,
  title={Negative glucocorticoid receptor response elements and their role in glucocorticoid action.},
  author={Anja Dostert and Thorsten Heinzel},
  journal={Current pharmaceutical design},
  year={2004},
  volume={10 23},
  pages={
          2807-16
        }
}
The glucocorticoid receptor (GR) belongs to the steroid hormone receptor subclass of nuclear receptors and controls physiological processes through activation and repression of specific target genes. The ligand-activated receptor dimer activates gene expression by binding to specific DNA sequences (glucocorticoid response element, GRE) in the promoter regions of glucocorticoid-regulated genes. In contrast to the regulation of these classical GREs, the repression of negatively regulated target… CONTINUE READING

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