Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

@article{Zhang2008NegativeFR,
  title={Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3},
  author={Min Zhang and Yang Tian and R J Wang and Dong Gao and Yan Zhang and Fei-Ci Diao and D. Chen and Zhong-He Zhai and Hong-Bing Shu},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={1096-1104}
}
Viral infection causes host cells to produce type I interferons (IFNs), which are critically involved in viral clearance. Previous studies have demonstrated that activation of the transcription factor interferon regulatory factor (IRF)3 is essential for virus-triggered induction of type I IFNs. Here we show that the E3 ubiquitin ligase RBCC protein interacting with PKC1 (RBCK1) catalyzes the ubiquitination and degradation of IRF3. Overexpression of RBCK1 negatively regulates Sendai virus… CONTINUE READING