Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.

@article{Mart2001NegativefeedbackRO,
  title={Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.},
  author={Francesc Soriguera Mart{\'i} and Anja Krause and Nicholas H. Post and Clay E. Lyddane and Bryony Dupont and Michel Sadelain and Philip D C King},
  journal={Journal of immunology},
  year={2001},
  volume={166 1},
  pages={197-206}
}
TCR and CD28 costimulatory receptor-cooperative induction of T cell IL-2 secretion is dependent upon activation of mitogen-activated protein (MAP) kinases. Using yeast-hybrid technology, we cloned a novel CD28 cytoplasmic tail (CD28 CYT) interacting protein, MAP kinase phosphatase-6 (MKP6), which we demonstrate inactivates MAP kinases. Several lines of evidence indicate that MKP6 plays an important functional role in CD28 costimulatory signaling. First, in human peripheral blood T cells (PBT… CONTINUE READING

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