Negative feedback loop of cholesterol regulation is impaired in the livers of patients with Alagille syndrome.

Abstract

AIM To characterize cholesterol regulation in the liver of patients with Alagille syndrome (AGS). METHODS Serum total cholesterol (TC) and total bile acid (TBA) levels were measured in 23 AGS patients. The expressions of genes involved in cholesterol regulation, including low-density lipoprotein receptor (LDLR), scavenger receptor class B type I (SR-BI… (More)
DOI: 10.1016/j.cca.2014.10.034

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