Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

@article{Rochais2004NegativeFE,
  title={Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.},
  author={Francesca Rochais and Gr{\'e}goire Vandecasteele and Florence Lefebvre and Claire Lugnier and Hazel Lum and Jean-Luc Mazet and Dermot M. F. Cooper and Rodolphe Fischmeister},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 50},
  pages={52095-105}
}
Intracardiac cAMP levels are modulated by hormones and neuromediators with specific effects on contractility and metabolism. To understand how the same second messenger conveys different information, mutants of the rat olfactory cyclic nucleotide-gated (CNG) channel alpha-subunit CNGA2, encoded into adenoviruses, were used to monitor cAMP in adult rat ventricular myocytes. CNGA2 was not found in native myocytes but was strongly expressed in infected cells. In whole cell patch-clamp experiments… CONTINUE READING
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