Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.

@article{Kim2010NegativeFC,
  title={Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.},
  author={Jung Ha Kim and Kabsun Kim and Hye Mi Jin and Insun Song and Bang Ung Youn and Seoung-Hoon Lee and Yongwon Choi and Nacksung Kim},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 8},
  pages={5224-31}
}
The regulation of NFATc1 expression is important for osteoclast differentiation and function. Herein, we demonstrate that macrophage-colony-stimulating factor induces NFATc1 degradation via Cbl proteins in a Src kinase-dependent manner. NFATc1 proteins are ubiquitinated and rapidly degraded during late stage osteoclastogenesis, and this degradation is mediated by Cbl-b and c-Cbl ubiquitin ligases in a Src-dependent manner. In addition, NFATc1 interacts endogenously with c-Src, c-Cbl, and Cbl-b… CONTINUE READING

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