Negative feedback by IRE1β optimizes mucin production in goblet cells.

@article{Tsuru2013NegativeFB,
  title={Negative feedback by IRE1β optimizes mucin production in goblet cells.},
  author={Akio Tsuru and Naoko Fujimoto and Satsuki Takahashi and Michiko Saito and Daisuke Nakamura and Megumi Iwano and Takao Iwawaki and Hiroshi Kadokura and David Ron and Kenji Kohno},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 8},
  pages={2864-9}
}
In mammals, the prototypical endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1 (IRE1) has diverged into two paralogs. IRE1α is broadly expressed and mediates the unconventional splicing of X-box binding protein 1 (XBP1) mRNA during ER stress. By contrast, IRE1β is expressed selectively in the digestive tract, and its function remains unclear. Here, we report that IRE1β plays a distinctive role in mucin-secreting goblet cells. In IRE1β(-/-) mice, aberrant mucin 2 (MUC2… CONTINUE READING
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References

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Showing 1-10 of 46 references

Mammalian ER stress sensor IRE 1 β speci fi cally downregulates the synthesis of secretory pathway proteins

D Nakamura
FEBS Lett • 2011

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 3 Excerpts

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