Negative feedback and physical limits of genes.

  title={Negative feedback and physical limits of genes.},
  author={Nicolae Radu Zabet},
  journal={Journal of theoretical biology},
  volume={284 1},
  • Nicolae Radu Zabet
  • Published 7 September 2011
  • Biology, Medicine
  • Journal of theoretical biology
This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non… 

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