Negative energy balance plays a major role in the IGF-I response to exercise training.

@article{Nemet2004NegativeEB,
  title={Negative energy balance plays a major role in the IGF-I response to exercise training.},
  author={Dan Nemet and Peter H Connolly and Andria M Pontello-Pescatello and Christie M Rose-Gottron and Jennifer K Larson and Pietro Renato Galassetti and Dan M. Cooper},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 1},
  pages={276-82}
}
Circulating IGF-I is correlated with fitness, but results of prospective exercise training studies have been inconsistent, showing both increases and decreases in IGF-I. We hypothesized that energy balance, often not accounted for, is a regulating variable such that training plus an energy intake deficit would cause a reduction in IGF-I, whereas training plus energy intake excess would lead to an increased IGF-I. To test this, 19 young, healthy men completed a 7-day strenuous exercise program… CONTINUE READING

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