Negative effect of antibodies against maxadilan on the fitness of the sand fly vector of American visceral leishmaniasis.

@article{Milleron2004NegativeEO,
  title={Negative effect of antibodies against maxadilan on the fitness of the sand fly vector of American visceral leishmaniasis.},
  author={Rania S Milleron and Jose M. Ribeiro and Dia Elnaime and Lynn Soong and Gregory C. Lanzaro},
  journal={The American journal of tropical medicine and hygiene},
  year={2004},
  volume={70 3},
  pages={278-85}
}
Lutzomyia longipalpis expresses a salivary protein called maxadilan (MAX) that functions to dilate vertebrate blood vessels and thereby to facilitate the sand fly's acquisition of blood. We hypothesized that antibodies specific for one of many MAX variants would inhibit vasodilatory function of that variant. In vitro and in vivo experiments showed that antibodies against a specific MAX variant decreased vasodilatory function. More specifically, antibodies against MAX blocked vasodilation of a… CONTINUE READING