• Biology, Medicine
  • Published in Immunology 1988

Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion.

@article{Gaudry1988NegativeEO,
  title={Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion.},
  author={Murielle Gaudry and Axel P{\'e}rianin and C Marquetty and Jacques Hakim},
  journal={Immunology},
  year={1988},
  volume={63 4},
  pages={
          715-9
        }
}
The effects of 1-(5-isoquinoline sulphonyl)-2-methyl piperazine (H-7), a recently described inhibitor of Ca2+/phospholipid-dependent protein kinase (protein kinase C), were studied during under-agarose migration of human polymorphonuclear neutrophils (PMN) stimulated by various chemoattractants, in order to determine whether protein kinase C is involved in PMN locomotion. The effect of H-7 on the oxidative burst induced by phorbol 12-myristate 13-acetate or N-formyl-methionyl-leucyl… CONTINUE READING