Negative effect of Hox gene expression on the development of the neural crest-derived facial skeleton.

@article{Creuzet2002NegativeEO,
  title={Negative effect of Hox gene expression on the development of the neural crest-derived facial skeleton.},
  author={Sophie E. Creuzet and G{\'e}rard Couly and Christine Vincent and Nicole M. Le Douarin},
  journal={Development},
  year={2002},
  volume={129 18},
  pages={
          4301-13
        }
}
Diencephalic, mesencephalic and metencephalic neural crest cells are skeletogenic and derive from neural folds that do not express Hox genes. In order to examine the influence of Hox gene expression on skull morphogenesis, expression of Hoxa2, Hoxa3 and Hoxb4 in conjunction with that of the green fluorescent protein has been selectively targeted to the Hox-negative neural folds of the avian embryo prior to the onset of crest cell emigration. Hoxa2 expression precludes the development of the… CONTINUE READING

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