Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3).

Abstract

Previous studies have shown that addition of interleukin-3 (IL-3) abrogated the B-cell potential of primary colonies supported by IL-11, erythropoietin, IL-7 and steel factor. However, the mechanism by which IL-3 exerts its inhibitory role is not understood. Using a variant of the mouse pro-B cell line Ba/F3 which expresses both IL-3 and IL-11 receptors, we… (More)

Topics

9 Figures and Tables

Cite this paper

@article{Magrangeas2001NegativeCB, title={Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3).}, author={Florence Magrangeas and Olivier Boisteau and Simone W Denis and Yannick Jacques and St{\'e}phane Minvielle}, journal={The Biochemical journal}, year={2001}, volume={353 Pt 2}, pages={223-30} }