Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.

@article{Zhang1999NegativeCB,
  title={Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.},
  author={P L Zhang and Gerhard Behre and Jing Pan and Atsushi Iwama and Nawarat Wara-aswapati and Hanna S. Radomska and Philip E. Auron and Daniel G Tenen and Zheng Sun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 15},
  pages={
          8705-10
        }
}

• P L Zhang, Gerhard Behre, +6 authors Zheng Sun
• Published 1999 in
  Proceedings of the National Academy of Sciences…

The process through which multipotential hematopoietic cells commit to distinct lineages involves the induction of specific transcription factors. PU.1 (also known as Spi-1) and GATA-1 are transcription factors essential for the development of myeloid and erythroid lineages, respectively. Overexpression of PU.1 and GATA-1 can block differentiation in lineages in which they normally are down-regulated, indicating that not only positive but negative regulation of these factors plays a role in… CONTINUE READING

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