Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.

@article{Zhang1999NegativeCB,
  title={Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.},
  author={P L Zhang and Gerhard Behre and Jing Pan and Atsushi Iwama and Nawarat Wara-aswapati and Hanna S. Radomska and Philip E. Auron and Daniel G Tenen and Zheng Sun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 15},
  pages={
          8705-10
        }
}
The process through which multipotential hematopoietic cells commit to distinct lineages involves the induction of specific transcription factors. PU.1 (also known as Spi-1) and GATA-1 are transcription factors essential for the development of myeloid and erythroid lineages, respectively. Overexpression of PU.1 and GATA-1 can block differentiation in lineages in which they normally are down-regulated, indicating that not only positive but negative regulation of these factors plays a role in… CONTINUE READING
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