Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.

  title={Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.},
  author={Lee E. Limbird and Robert J Lefkowitz},
  journal={The Journal of biological chemistry},
  volume={251 16},
(-)-[3H]Dihydroalprenolol, a potent competitive beta-adrenergic antagonist, has been previously documented to bind to the adenylate cyclase-coupled beta-adrenergic receptor sites in mammalian and non-mammalian tissues. Steady state binding of (-)-[3H]dihydroalprenolol to sites in frog erythrocyte membranes, a model system for adenylate cyclase-coupled beta-adrenergic receptors, displays characteristics consistent with negative cooperativity among the beta-adrenergic receptors: Scatchard plots… CONTINUE READING


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