Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.

@article{Limbird1976NegativeCA,
  title={Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.},
  author={Lee E. Limbird and Robert J Lefkowitz},
  journal={The Journal of biological chemistry},
  year={1976},
  volume={251 16},
  pages={5007-14}
}
(-)-[3H]Dihydroalprenolol, a potent competitive beta-adrenergic antagonist, has been previously documented to bind to the adenylate cyclase-coupled beta-adrenergic receptor sites in mammalian and non-mammalian tissues. Steady state binding of (-)-[3H]dihydroalprenolol to sites in frog erythrocyte membranes, a model system for adenylate cyclase-coupled beta-adrenergic receptors, displays characteristics consistent with negative cooperativity among the beta-adrenergic receptors: Scatchard plots… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Pathway and mechanism of drug binding to G-protein-coupled receptors.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 8 Excerpts
Highly Influenced

Escorts take the lead molecular chaperones as therapeutic targets.

Progress in molecular biology and translational science • 2010

Similar Papers

Loading similar papers…