Negative control contributes to an extensive program of meiotic splicing in fission yeast.

@article{Averbeck2005NegativeCC,
  title={Negative control contributes to an extensive program of meiotic splicing in fission yeast.},
  author={Nicole Averbeck and Sham Sunder and Nicole Sample and Jo Ann Wise and Janet Leatherwood},
  journal={Molecular cell},
  year={2005},
  volume={18 4},
  pages={491-8}
}
Despite a high frequency of introns in the fission yeast Schizosaccharomyces pombe, regulated splicing is virtually unknown. We present evidence that splicing constitutes a major mechanism for controlling gene expression during meiosis, as 12 of 96 transcripts tested, which encode known components as well as previously uncharacterized ORFs, retain introns until specific times during differentiation. The meiotically spliced pre-mRNAs include two cyclins, rem1 (discovered by Ayte and Nurse) and… CONTINUE READING

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