Negative chronotropic effect of endothelin 1 mediated through ETA receptors in guinea pig atria.

@article{Ono1995NegativeCE,
  title={Negative chronotropic effect of endothelin 1 mediated through ETA receptors in guinea pig atria.},
  author={Kageyoshi Ono and Koji Eto and Atsuo Sakamoto and Tsutomu Masaki and Katsuhiro Shibata and Toshikatsu Sada and Katsuji Hashimoto and Gozoh Tsujimoto},
  journal={Circulation research},
  year={1995},
  volume={76 2},
  pages={
          284-92
        }
}
Endothelins exert potent excitatory cardiac effects by acting on specific receptors on myocytes. In this study, we have examined the signal transduction mechanism for the chronotropic effect of endothelins in guinea pig atria. A competition binding of [125I]endothelin 1 ([125I]ET-1) using the recently developed ETA receptor-selective antagonist BQ123 showed the presence of almost equal populations of ETA (44%) and ETB (56%) receptors in the guinea pig right atria. In a concentration-response… CONTINUE READING
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