Negative biomarker-based male fertility evaluation: sperm phenotypes associated with molecular-level anomalies

@inproceedings{Sutovsky2015NegativeBM,
  title={Negative biomarker-based male fertility evaluation: sperm phenotypes associated with molecular-level anomalies},
  author={Peter Sutovsky and Mahmoud Aarabi and Antonio Miranda-Vizuete and Richard J Oko},
  booktitle={Asian journal of andrology},
  year={2015}
}
Biomarker-based sperm analysis elevates the treatment of human infertility and ameliorates reproductive performance in livestock. The negative biomarker-based approach focuses on proteins and ligands unique to defective spermatozoa, regardless of their morphological phenotype, lending itself to analysis by flow cytometry (FC). A prime example is the spermatid specific thioredoxin SPTRX3/TXNDC8, retained in the nuclear vacuoles and superfluous cytoplasm of defective human spermatozoa. Infertile… CONTINUE READING

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