Negative and positive effects of intracerebroventricular scopolamine on memory in mice undergoing passive avoidance and escape tests.

@article{Nakajima1994NegativeAP,
  title={Negative and positive effects of intracerebroventricular scopolamine on memory in mice undergoing passive avoidance and escape tests.},
  author={Mikako Nakajima and Akio Inui and Midori Miura and Yoshiaki Hirosue and Motoichi Okita and Norio Himori and Shigeaki Baba and Masato Kasuga},
  journal={Brain research bulletin},
  year={1994},
  volume={34 4},
  pages={375-80}
}
The effects of intracerebroventricular administration of scopolamine on memory and learning in the conscious, freely moving mouse were evaluated using step-down passive avoidance and water maze tests. A new technique was used that allows convenient injection into the cerebral ventricles without disturbing the animal's behavior. No significant changes in locomotor activity were observed after low doses of scopolamine (0.1 and 1.0 microgram). However, 10 micrograms produced an increase in… CONTINUE READING