Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip*

  title={Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip*},
  author={Guolong Zhang and Sankar Kumar Ghosh},
  journal={The Journal of Biological Chemistry},
  pages={7059 - 7065}
Toll-like receptor (TLR)-mediated recognition of pathogens represents one of the most important mechanisms of innate immunity and disease resistance. The adaptor protein Tollip was identified initially as an intermediate in interleukin (IL)-1 signaling. Here we report that Tollip also associates directly with TLR2 and TLR4 and plays an inhibitory role in TLR-mediated cell activation. Inhibition by Tollip is mediated through its ability to potently suppress the activity of IL-1 receptor… 

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