Negative Parafibromin Staining Predicts Malignant Behavior in Atypical Parathyroid Adenomas

@article{Kruijff2013NegativePS,
  title={Negative Parafibromin Staining Predicts Malignant Behavior in Atypical Parathyroid Adenomas},
  author={Schelto Kruijff and Stan B. Sidhu and MMed Sci Mark S. Sywak MBBS and Anthony J Gill and Leigh Walter Delbridge},
  journal={Annals of Surgical Oncology},
  year={2013},
  volume={21},
  pages={426-433}
}
The histopathological criteria for carcinoma proposed by the World Health Organization (WHO) are imperfect predictors of the malignant potential of parathyroid tumors. Negative parafibromin (PF) and positive protein gene product 9.5 (PGP9.5) staining are markers of CDC73 mutation and occur commonly in carcinoma but rarely in adenomas. We investigated whether PF and PGP9.5 staining could be used to predict the behavior of atypical parathyroid adenomas—tumors with atypical features that do not… CONTINUE READING
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