Negative Modeling Results: A Dime a Dozen or a Stepping Stone to Scientific Discovery?

@inproceedings{Hendriks2013NegativeMR,
  title={Negative Modeling Results: A Dime a Dozen or a Stepping Stone to Scientific Discovery?},
  author={Bart S. Hendriks},
  booktitle={CPT: pharmacometrics & systems pharmacology},
  year={2013}
}
Systems pharmacology models, in general, tend to span multiple timescales bridging detailed mechanism with higher level responses or functional outputs. These features serve to put systems pharmacology models in a separate class that brings with it specific challenges, particularly in evaluating such work. When models are constructed on well-understood… CONTINUE READING