Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

@article{Matsuzawa2008NegativeCB,
  title={Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study},
  author={Daisuke Matsuzawa and Takayuki Obata and Yukihiko Shirayama and Hiroi Nonaka and Yoko Kanazawa and Eiji Yoshitome and Junichi Takanashi and Tsuyoshi Matsuda and Eiji Shimizu and Hiroo Ikehira and Masaomi Iyo and Kenji Hashimoto},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1 - 17}
}
BACKGROUND Glutathione (GSH), a major intracellular antioxidant, plays a role in NMDA receptor-mediated neurotransmission, which is involved in the pathophysiology of schizophrenia. In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in patients. METHODS AND FINDINGS Twenty schizophrenia patients and 16 age- and gender… CONTINUE READING
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