Nefopam enantiomers: preclinical pharmacology/toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration.

@article{Mather2000NefopamEP,
  title={Nefopam enantiomers: preclinical pharmacology/toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration.},
  author={Gary G. Mather and R B Labroo and M E Le Guern and Francis Lepage and Jean Marie Gillardin and Ren{\'e} H. Levy},
  journal={Chirality},
  year={2000},
  volume={12 3},
  pages={153-9}
}
Nefopam (NEF) is a potent analgesic compound administered as a racemic mixture. Previous in vitro and in vivo studies with nefopam enantiomers have shown that (+)nefopam [(+)NEF] is substantially more potent than (-)nefopam [(-)NEF]. Differences between enantiomers have also been suggested in metabolic studies in vitro. The impact of these differences in vivo is not known because there is little or no information on the relative plasma concentrations of the enantiomers or on their kinetics. In… CONTINUE READING