Nefopam and morphine in man

@article{Sunshine1975NefopamAM,
  title={Nefopam and morphine in man},
  author={Abraham Sunshine and Eugene M. Laska},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1975},
  volume={18}
}
A new analgesic, nefopam, is chemically distinct and pharmacologically unrelated to any presently known analgesic. A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design. A significant dose‐response curve was obtained with nefopam and with morphine, and there was no significant deviation from parallelism. The time‐effect curves for the 2… Expand

Paper Mentions

Interventional Clinical Trial
Nefopam is a benzoxazocine derivative which is non-opioid and non NSAIDs. The previous studies showed that nefopam can inhibit reuptake of serotonin, norepinephrine and dopamine… Expand
ConditionsCervical Spine Degeneration
InterventionDrug
A comparison of a new analgesic, nefopam hydrochloride, with morphine sulphate, pentazocine and pethidine hydrochloride in post-operative pain
TLDR
It is suggested that nefopam is a sufficiently potent analgesic agent to control post-operative pain, with a relatively low incidence of side-effects. Expand
In vitro biochemical effects of nefopam hydrochloride, a new analgesic agent.
TLDR
Nefopam hydrochloride (Acupan) was a very weak inhibitor of [3H]naloxone binding to brain homogenates and nefopam was a potent inhibitor of synaptosomal uptake of dopamine, norepinephrine, and serotonin. Expand
The Clinical Analgesic Efficacy of Oral Nefopam Hydrochloride
TLDR
The analgesic efficacy of 60 and 120 mg nefopam hydrochloride was compared to 650 mg aspirin and placebo in a double-blind single-dose study of patients suffering from acute postsurgical or fracture pain. Expand
The Analgesic and Hypothermic Effects of Nefopam, Morphine, Aspirin, Diphenhydramine, and Placebo
TLDR
No statistically significant differences in pain intensity or relief were seen for nefopam (Acupan), diphenhydramine (Benadryl), aspirin, or placebo despite a numerically higher score for ne fopam despite a unexpectantly high placebo response. Expand
Oral nefopam and aspirin
TLDR
Treatment effects were consistent and indicative of good dose response to both active medications, and pain relief scores were more variable but were generally in accordance with SPID values. Expand
Nefopam and Ketamine Comparably Enhance Postoperative Analgesia
TLDR
Tachycardia and profuse sweating were more frequent in patients given nefopam, and sedation was more intense with ketamine; however, the incidence of other potential complications did not differ among groups. Expand
A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain
TLDR
Nefopam is chemically Gasse13 recognized that the drug had an unrelated to any known class of analgesics analgesic effect in his human experimental and is pharmacologically distinct from model for muscle relaxant activity. Expand
The effects of nefopam on blood acid‐base status in the rabbit: interactions with morphine in the mouse and rabbit
TLDR
Nefopam, a non‐narcotic analgesic, had only minor effects upon the blood pH, Pco2 and standard bicarbonate of the conscious rabbit, and when nefopam was administered in conjunction with morphine the increase in P co2 was greater than with morphine alone. Expand
A comparative assay of nefopam, morphine and d-amphetamine
TLDR
In the authors' opinion, nefopam has a lesser potential to be abused than morphine or d- methamphetamine, and is neither entirely morphine-like nor d-amphetamine-like. Expand
Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy
TLDR
Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine. Expand
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