Nefopam and morphine in man

  title={Nefopam and morphine in man},
  author={Abraham Sunshine and Eugene M Laska},
  journal={Clinical Pharmacology \& Therapeutics},
  • A. SunshineE. Laska
  • Published 1 November 1975
  • Medicine, Biology
  • Clinical Pharmacology & Therapeutics
A new analgesic, nefopam, is chemically distinct and pharmacologically unrelated to any presently known analgesic. A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design. A significant dose‐response curve was obtained with nefopam and with morphine, and there was no significant deviation from parallelism. The time‐effect curves for the 2… 

A comparison of a new analgesic, nefopam hydrochloride, with morphine sulphate, pentazocine and pethidine hydrochloride in post-operative pain

It is suggested that nefopam is a sufficiently potent analgesic agent to control post-operative pain, with a relatively low incidence of side-effects.


  • Medicine
  • 2008
The purpose of the present double-blind parallel study was to compare the analgesic activity of nefopam hydrochloride relative to propoxyphene hydrochlorides and a placebo when administered by mouth.

The Clinical Analgesic Efficacy of Oral Nefopam Hydrochloride

The analgesic efficacy of 60 and 120 mg nefopam hydrochloride was compared to 650 mg aspirin and placebo in a double-blind single-dose study of patients suffering from acute postsurgical or fracture pain.

The Analgesic and Hypothermic Effects of Nefopam, Morphine, Aspirin, Diphenhydramine, and Placebo

No statistically significant differences in pain intensity or relief were seen for nefopam (Acupan), diphenhydramine (Benadryl), aspirin, or placebo despite a numerically higher score for ne fopam despite a unexpectantly high placebo response.

Oral nefopam and aspirin

Treatment effects were consistent and indicative of good dose response to both active medications, and pain relief scores were more variable but were generally in accordance with SPID values.

Nefopam and Ketamine Comparably Enhance Postoperative Analgesia

Tachycardia and profuse sweating were more frequent in patients given nefopam, and sedation was more intense with ketamine; however, the incidence of other potential complications did not differ among groups.

A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain

Nefopam is chemically Gasse13 recognized that the drug had an unrelated to any known class of analgesics analgesic effect in his human experimental and is pharmacologically distinct from model for muscle relaxant activity.

The effects of nefopam on blood acid‐base status in the rabbit: interactions with morphine in the mouse and rabbit

Nefopam, a non‐narcotic analgesic, had only minor effects upon the blood pH, Pco2 and standard bicarbonate of the conscious rabbit, and when nefopam was administered in conjunction with morphine the increase in P co2 was greater than with morphine alone.

Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine.



A bioassay computer program for analgesic clinical trials

A Fortran program to calculate estimates of relative potency of a test to a standard analgesic is described and the rationale behind the approach adopted in the program is discussed.

A clinical evaluation of nefopam hydrochloride (Acupan): a new analgesic.

Long-term safety of Nefopam hydrochloride (Acupan), a new analgesic formulation.

  • A. Klotz
  • Medicine
    Current therapeutic research, clinical and experimental
  • 1974

A uniform method for collecting and processing analgesic data.

Nefopam hydrochloride for pain relief.

  • A. Cohen
  • Medicine
    Current therapeutic research, clinical and experimental
  • 1974

Nefopam hydrochloride for pain

  • relief, Curro Ther. Res
  • 1974

Controlled clinical trial of oral and parenteral nefopam HCI , a novel and potent analgesic drug , In press