Nefopam and morphine in man

  title={Nefopam and morphine in man},
  author={A. Sunshine and E. Laska},
  journal={Clinical Pharmacology & Therapeutics},
  • A. Sunshine, E. Laska
  • Published 1975
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • A new analgesic, nefopam, is chemically distinct and pharmacologically unrelated to any presently known analgesic. A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design. A significant dose‐response curve was obtained with nefopam and with morphine, and there was no significant deviation from parallelism. The time‐effect curves for the 2… CONTINUE READING
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