Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

@article{Heel2012NefopamAR,
  title={Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy},
  author={Rennie C. Heel and Rex N. Brogden and Gary E. Pakes and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={19},
  pages={249-267}
}
SummarySynopsis: Nefopam1 is a non-narcotic analgesic not structurally related to other analgesic drugs. It is effective by the oral and parenteral routes, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentazocine. However, when ‘higher’ dose ratios were compared, morphine and… Expand
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References

SHOWING 1-10 OF 64 REFERENCES
Buprenorphine: A Review of its Pharmacological Properties and Therapeutic Efficacy
TLDR
Buprenorphine appears to produce side effects which are similar to those seen with other morphine- like compounds, including respiratory depression, and animal studies and a direct addiction study in a few volunteers suggest that the dependence liability of buprenorphines may be lower than that of other older morphine-like drugs. Expand
Butorphanol: A Review of its Pharmacological Properties and Therapeutic Efficacy
TLDR
Studies in animal models and in a few volunteers have suggested that butorphanol may have a lower dependence liability than narcotic drugs such as morphine or pethidine, and if this is indeed the case it will offer an important advantage over these agents. Expand
Controlled Clinical Trial of Oral and Parenteral Nefopam Hydrochloride. A Novel and Potent Analgesic Drug
TLDR
Nefopam is a potent analgesic of novel structure and unique physiologic properties that is distinctly superior to placebo in analgesic effectiveness, both in the initial single dose and in maintaining therapeutic benefit for the duration of the three-day trial. Expand
Nefopam Hydrochloride*: New Analgesic Agent
TLDR
Time-course action of the drugs revealed that aspirin 300 mg failed to achieve statistically significant analgesia at any post-treatment observation, whereas nefopam 60 mg was significantly better than placebo at one and three hours in terms of pain intensity and at one hour in termsof pain intensity difference scores. Expand
Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain
TLDR
Drowsiness and a decrease in the respiratory rate were the principal side‐effects of oxycodone, whereas tachycardia, restlessness, sweating and nausea were more frequent after nefopam. Expand
Nefopam and morphine in man
TLDR
A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design. Expand
A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain
TLDR
Nefopam is chemically Gasse13 recognized that the drug had an unrelated to any known class of analgesics analgesic effect in his human experimental and is pharmacologically distinct from model for muscle relaxant activity. Expand
Oral nefopam and aspirin
TLDR
Treatment effects were consistent and indicative of good dose response to both active medications, and pain relief scores were more variable but were generally in accordance with SPID values. Expand
Comparison of nefopam and pethidine in postoperative pain.
TLDR
A double-blind, between-patient, two-dose comparison was performed with pethidine and nefopam in 100 subjects, the majority of whom were recovering from upper abdominal surgery, finding the former being not more effective than neFopam 15 mg apart from the duration of analgesia which was longer. Expand
Gastrointestinal Blood Loss Study with a New Analgesic Compound: Nefopam Hydrochloride
  • B. Baltes
  • Medicine
  • Journal of clinical pharmacology
  • 1977
TLDR
A new analgesic compound, nefopam HCl, was studied for possible gastrointestinal blood loss liabilities by Cr-51 red cell tagging and showed a significant increase in occult bleeding in the aspirin-treated subjects, compared with aspirin in usual therapeutic doses. Expand
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