Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

@article{Heel2012NefopamAR,
  title={Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy},
  author={Rennie C. Heel and Rex N. Brogden and Gary E. Pakes and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={19},
  pages={249-267}
}
SummarySynopsis: Nefopam1 is a non-narcotic analgesic not structurally related to other analgesic drugs. It is effective by the oral and parenteral routes, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentazocine. However, when ‘higher’ dose ratios were compared, morphine and… Expand
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Nefopam analgesia and its role in multimodal analgesia: A review of preclinical and clinical studies
TLDR
A review of nefopam combinations including various analgesic drugs (opioids, NSAIDs and paracetamol) reveals that enhanced analgesia was demonstrated in most preclinical and clinical studies, suggesting a role for ne fopam in multimodal analgesia based on its distinct characteristics as an analgesic. Expand
Rediscovery of Nefopam for the Treatment of Neuropathic Pain
TLDR
The recently discovered dual analgesic mechanisms of action, namely, descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain. Expand
Nefopam and ketoprofen synergy in rodent models of antinociception.
TLDR
Co-administration of nefopam with ketoprofen is synergistic, and should allow either to increase their analgesic efficacy and/or to reduce their side effects. Expand
Non-Steroidal Anti-Inflammatory Analgesics Other than Salicylates
TLDR
Few clinically significant drug interactions are associated with concomitant administration of the arylalkanoic acids or piroxicam and other drugs, but there is a theoretical potential for displacement reactions with drugs that are used at plasma concentrations high enough to exceed the binding capacity of their own primary binding sites. Expand
Intravenous Nefopam Reduces Postherpetic Neuralgia during the Titration of Oral Medications
TLDR
An intravenous continuous infusion of NFP reduces spontaneous and evoked neuropathic pain with tolerable adverse effects during the titration of oral medications in inpatients with postherpetic neuralgia. Expand
Status Epilepticus Caused by Nefopam
TLDR
Physicians should be aware of the possible occurrence of unpredictable and serious convulsions when using nefopam, and identify the introduced drugs and exclude the possibility of an accidental misuse of other drugs. Expand
Compartmental pharmacokinetics of nefopam during mild hypothermia.
TLDR
A two-compartment mammillary model with moderate inter-individual variability and inter-occasional variability independent of covariates was found to best describe the pharmacokinetics of nefopam and could be implemented to drive automated pumps. Expand
Nefopam Hydrochloride: A Fatal Overdose.
TLDR
An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis, attributing death to atherosclerotic coronary artery disease and therapeutic drug toxicity. Expand
Old is Gold? Nefopam Hydrochloride, a Non-opioid and Non-steroidal Analgesic Drug and Its Practical One-Pot Synthesis in a Single Solvent for Large-Scale Production
Nefopam hydrochloride is extensively used in most of the European countries until today as an analgesic because of its non-opiate (non-narcotic) and non-steroidal action with fewer side effects… Expand
Population pharmacokinetics of nefopam in elderly, with or without renal impairment, and its link to treatment response.
TLDR
Tachycardia and postoperative nausea and vomiting were best associated with maximal concentration and the rate of increase in nefopam plasma concentration, and Morphine requirement was related to exposure of ne fopam. Expand
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